The T-TIP agreement aims to get rid of trade barriers between Europe and the United States.
Demonstrators are meeting at Central Bank on Dame Street from 1 o'clock this afternoon.
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Organisers of today's protest say they're worried about what the T-TIP agreement could do to manufacturing standards and workers' rights in the EU and in Ireland.
Barry Finnegan is a researcher with the Irish branch of the civil society group, ATTAC
He says the Dublin protest will coincide with other demonstrations around Europe today