The man – who was in his 60s – was struck by a blue BMW with a partial registration 01-G on the Gort Road in Loughrea at about half past eight.
Gardaí say the car drove away from the scene in the direction of Gort.
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The victim was taken to University College Hospital Galway where he was pronounced dead shortly before 2am.
The road remains closed this morning for a forensic examination – and Gardaí are appealing for any witnesses to come forward.