The single vehicle collision happened in the Silvermines area at around 3 o'clock this afternoon.
The female driver, who was the only occupant, died after her car hit a wall at Ballintogher.
She was pronounced dead at the scene and her body has been removed to Limerick University Hospital for a post-mortem.
The road has been closed to facilitate a Garda Forensic Collision Examination and local diversions are in place.
Nenagh gardaí who are investigating the fatal road crash are appealing for anyone with information to contact them on 067-50450, the Garda Confidential Line 1800 666 111 or any Garda Station.
