Spurs are first up. They've travelled to take on KAA Gent at 6 o'clock, with both sides coming into the game on the back of domestic defeats.
Spurs will be without Erik Lamela, Jan Vertonghen and Danny Rose.
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United, meanwhile, will be without Wayne Rooney, Michael Carrick and Phil Jones due to injury and there still isn't room for Luke Shaw in their squad.
They're up against Saint Etienne at Old Trafford.
Kick off is at 5 past 8.
