Back row Tommy O'Donnell has been included in the Munster team for the clash at Rugby park in Kilmarknock.
The Cahir man came off the bench for Ireland against France last week and started the week before against Wales.
Nenagh's Donnacha Ryan starts in the second row while James Cronin is on the bench.
Dave Foley from Clonmel is among the replacements for the trip to Scotland.
The reds need a win as they currently lie sixth in the league 7 points off the top 4.
