Nenagh Ormond – who lost for the first time this season in Division 2A last time out at Malone – face table-toppers Banbridge on home turf.
Cashel are looking to make it two wins out of two – they meet bottom of the table Belfast Harlequins at Deramore Park.
The action at both venues begins at 2.30pm.
Meanwhile, Munster are top of the Guinness Pro12 table after a third straight win in all competitions.
Rassie Eramus's side were comfortable 33-0 winners at home to the Ospreys in Cork last night.
However there was disappointment for Ulster and Connacht as they both fell to away defeats.
Ulster lost out to Edinburgh by 28 points to 17, while the Dragons defeated Connacht 21-16.
Today a new look Leinster side are in Italy to face Zebre at 4.05pm.
