Lucas and Sakho are also doubts but Martin Skrtel could return.
City boss Manuel Pellegrini says that former Red Raheem Sterling will start.
Spurs can go top with a win at West Ham but they may have to do it without Dele Alli who's an injury doubt.
In the nights other ties Arsenal welcome Swansea, Manchester United host Watford and Stoke take on Newcastle.
The games at Anfield and Old Trafford start at 8 with the rest off at 7.45
