Nenagh native Donnacha Ryan will partner Billy Holland in the second row while Cahir man Tommy O'Donnell is selected in the back row alongside captain Peter O'Mahoney and CJ Stander.
Otherwise, Rassie Erasmus has made just one change from the side beaten by Leinster in the Pro12 last weekend.
With Keith Earls still following return to play protocols, South African international Jaco Taute will make his European debut for the province at outside centre.
There's better news for Dave Kilcoyne who has now completed his return to play protocols and will start in the front row.
