Captain Jose Fonte is expected to play for the Saints after missing last week due to a late return from pre-season.
It's also likely that world record signing Paul Pogba will get some game time for the Red Devils.
There's also one game tonight in the Airtricity League Premier Division.
Galway United will host Bray Wanderers in a 7.45 start at Eamonn Deacy Park.
In the Irish Daily Mail FAI Cup Athlone Town host Shamrock Rovers, while Bohemians face Derry City at Dalymount Park.
St Pat's will take-on Limerick at Richmond Park.
Those three games all kick-off at 7.45, while there's an 8 o'clock start between Wexford Youths and Sligo Rovers in Ferrycarrig Park.
