Munster back-row Peter O'Mahony has been ruled out for the rest of the tournament with a knee ligament injury.
Paul O'Connell and Johnny Sexton are also on the injured list and will undergo scans today.
Neither man has been ruled out of the next match but its thought O'Connell is highly unlikely to face the Puma's this Sunday in Cardiff.
Full back Rob Kearney who says as difficult as the situation is the players must keep their focus.
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