It's being billed as the biggest North London for decades as both sides seek to maintain their push for the title after mid-week losses.
Spurs start the day in second place and three points behind leaders Leicester City, with Arsenal a further three points back in third.
That's the early game today in the Premier League, with kick-off at White Heart Lane at 12:45.
Leaders Leicester are involved in the late game when they travel to face Watford in a half-five start.
In between there's six 3 o'clock kick-offs today in the English top-flight.
Fourth-placed Man City will host Aston Villa while Chelsea will hope to continue their excellent run of form as they're at home to Stoke and West Ham visit Everton.
In the relegation scrap, Newcastle and Norwich will both be hoping to climb out of the bottom three as they face Bournemouth and Swansea respectively while Sunderland will be hoping to stay out of trouble as they visit Southampton.
