Tipperary's Tommy O'Donnell has been ruled out of the clash due to an ankle injury he sustained during last Saturday's PRO 12 victory over Connacht.
Elsewhere and
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Jonathan Sexton makes his first start since October tonight as Leinster welcome Zebre to the RDS in the Pro 12.
Leinster go into the weekend third in the table, and kick off in Ballsbridge is at 7.35.
At the same time, Ulster will look to bounce back from last week's defeat to Leinster.
They welcome back a host of internationals, including captain Rory Best, for their trip to the Scarlets.
Tonight's other game sees third-bottom Dragons face second-bottom Treviso.
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