Tries from Ronan O'Mahony, CJ Stander, Conor Murray, two from Simon Zebo – who is now the province's leading try scorer – and two penalty tries helped them into fourth place in the Pro12 table.
The win was the biggest Munster have ever in the league.
And they are still ahead of Ulster in the table as Les Kiss's side let an 8-point lead slip at Scotstoun to lose 27-17 against Glasgow.
Stuart McCloskey and Iain Henderson had helped them into a 17-9 lead, but Tommy Seymour and Stuart Hogg scored a try each in the space of 3 minutes to turn the game on its head.
