Head Coach Anthony Foley has once again retained Tipperary's Tommy O' Donnell and Dave Foley in his side.
James Cronin and former Springbok BJ Botha replace Dave Kilcoyne and Stephen Archer in the front row .
Both teams won their opening matches last week, with the Reds beating Sale by one point and Sarries overcoming Clermont by 7 points at home.
Saracens have four changes in their starting XV, including the selection of England international Owen Farrell at out half.
Munster XV (v Sacacens, Friday, Thomond Park, 7:45pm): Felix Jones, Andrew Conway, Andrew Smith, Denis Hurley, Simon Zebo; Ian Keatley, Conor Murray; James Cronin, Duncan Casey, BJ Botha; Dave Foley, Paul O'Connell; Peter O'Mahony – capt, Tommy O'Donnell, CJ Stander
Replacements: Eusebio Guinazu, Dave Kilcoyne, Stephen Archer, Billy Holland, Robin Copeland, Duncan Williams, JJ Hanrahan, Gerhard van den Heever
