Ronan O'Mahony replaces Keith Earls on the wing for the hosts while Francis Saili is on the bench and could play for the first time this season.
In the pack James Cronin and Jean Kleyn slot into the front and second rows respectively.
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Tipperary men Donnacha Ryan and Tommy O'Donnell are also in the XV for the Thomond Park clash.
Munster Director of Rugby Rassie Erasmus is looking forward to the game and says they'll need to improve on the display in their defeat to Leicester in the Champions cup last weekend.
