Cashel went down 20-18 against table-toppers Banbridge.
Despite leading for a good proportion of the fixture at Spafield the home side couldn't avoid a second defeat of the season against the Down team.
Nenagh Ormond eased their relegation worries by beating Skerries 30-15 at Holmpatrick.
Kolio Hifo scored two tries for Ormond with Anthony Grey and Derek Corcoran getting one a piece.
Mike Walsh kicked two penalties and a conversion while Hifo also added a conversion.