Rob Kearney returns at full back while Luke Fitzgerald is on the wing.
Luke McGrath partners Ian Madigan in the half backs.
It's all change in the front row as Cian Healy, Richardt Strauss and Mike Ross all come in while Rhys Ruddock captains Leinster from the back row alongside Josh van der Flier, who will make his twelfth start of the season, and Jordi Murphy, who starts at number 8.
Leinster lead the Pro 12 but are level on points with Connacht who host Munster on Saturday.
