The Foxes, who have only lost three games this season, need just one more win to be guaranteed the title.
United are chasing the points in their battle for a top-four finish with action underway at Old Trafford from five-past two.
Leicester boss Claudio Ranieri says they're keeping their feet firmly on the ground.
Meanwhile, Liverpool will look to put their Europa League loss to Villarreal behind them as they go to Swansea from midday.
Man City will be looking to strengthen their grip on a Champions League place with a win at Southampton from half-four.
