Joe Schmidt's side are in Chicago to face a New Zealand side who are overwhelming favourites to come out on top after winning their last 18 games in all competitions.
The Ireland head coach has opted for experience in his starting 15, with Rob Kearney and Jared Payne named at full-back and centre respectively.
Tipperary's Donnacha Ryan is also in the team.
Meanwhile, the All Blacks have recalled Aaron Smith at scrum-half after missing their win over Australia through suspension.
Prop Jack McGrath is well aware of the task facing the side this evening.
Kick off in Chicago is at 8.00pm Irish time.
Also in the Autumn Internationals today, Wales and Australia resume their rivalry at the Principality Stadium at 2.30pm, and then at 3.30pm the Barbarians face South Africa at Wembley.
