Simon Zebo starts at full-back, with Tommy Bowe and Jared Payne restored to the back line.
Paul O'Connell captains the side for the 25th time, and he's partnered in the second row by Devon Toner.
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Kick off at Twickenham is at 2.30.
Meanwhile Ulster opened up their Pro 12 campaign last night with a bonus point 28-6 win over Ospreys at Kingspan Ravenhill.
Connacht edged out the Dragons by 29-points to 23
While Leinster went down 16-9 away to Edinburgh.
Tonight, Munster begin their campaign with the visit of Treviso to Irish Independent Park.
