Simon Zebo starts at full-back, with Tommy Bowe and Jared Payne restored to the back line.
Paul O'Connell captains the side for the 25th time, and he's partnered in the second row by Devon Toner.
Kick off at Twickenham is at 2.30.
Meanwhile Ulster opened up their Pro 12 campaign last night with a bonus point 28-6 win over Ospreys at Kingspan Ravenhill.
Connacht edged out the Dragons by 29-points to 23
While Leinster went down 16-9 away to Edinburgh.
Tonight, Munster begin their campaign with the visit of Treviso to Irish Independent Park.
