Kick off is at 7.45 with a win vital for the Irish side.
The Republic face the Group D minnows having already put seven past them without reply in the reverse fixture at the Aviva Stadium in October last year.
However, complacency is simply not on the agenda as Martin O'Neill and his assistant Keane prepare for the clash with the Gibraltarians, and Georgia's visit to Dublin three days later, knowing six points is a must if they are to retain hope of qualification.
Keane said: “First and foremost, you want to win the game of football. it's in our mindset that we can score one goal, two, seven, whatever it might be.
Meanwhile, Northern Ireland could end up top of their qualifying group this evening.
They're just one point behind leaders Romania going into their match away to the Faroe Islands.
Wales are a win away from qualifying for Euro 2016.
They beat Cyprus 1-0 last night, and it means a victory over Israel in Cardiff on Sunday would send them to the finals in France.
