The home side will be without the likes of Robbie Keane, Jonathan Walters, Jeff Hendrick and Harry Arter for tonight's game.
But O'Neill has indicated that he wants to give likes of Shane Duffy, Stephen Gleeson and Alan Judge a chance to make an impression over the next two matches.
However, the Ireland manager has also admitted that the latecomers to his squad are at a disadvantage for Euro2016.
