The local derby saw Kenny O'Shea's side defeat Paul Scully's Clonmel Town.
The full time score was Clonmel Town 1 Clonmel Celtic 2.
Clonmel Celtic now join St Michaels in the last eight of the competition.
Stevie O'Donnell was at the game for Tipp FM Sport.
In the FAI Youth Cup 4th Round it finished Woodslawn Sportslink of Dublin 2 Clonmel Town 5.
And in the North Tipp Premier Division League it finished Nenagh Celtic 2-0 Sallypark.
