Louis Van Gaal's team are unbeaten in their last 11 games but have won just 4 of those matches.
If United lose and PSV Eindhoven win or draw at home against CSKA Moscow the Dutch side will go through.
Manchester City are already through but a win at home to Borussia Monchengladbach ( Monch-en-glad-bach) coupled with a Juventus loss to Sevilla will see them win the group.
Manager Manuel Pellegrini says despite already having qualified – that would be a big boost.
There's good news for Chelsea ahead of tomorrows meeting with FC Porto.
John Terry trained with the squad this morning.
The defender hasn't played the 4-0 win against Maccabi Tel Aviv two weeks ago.