Leaders Dundalk have made the long journey to Donegal to face Finn Harps, while second-placed Cork City will be hoping to close the four-point gap at the top of the table.
The Leesiders are preparing to host fourth-placed Derry City at Turner's Cross, which is the only 7:45 start tonight in the Premier Division.
The action at Finn Park will kick-off at 8pm, which is also the start time for the other two matches in the top-flight as St Pat's host Longford Town and Wexford Youths go up against Shamrock Rovers.
In the First Division, leaders Limerick are at home to Athlone Town in a 7.15 start.
Elsewhere, Drogheda United go up against Shelbourne, UCD host Cobh Ramblers and Cabinteely go to the RSC to take-on Waterford United.
