Clare are aiming for their first league title in 38 years while Waterford are the defending Champions.
Clare midfielder Colm Galvin says Waterford will be tough to beat.
The action gets underway at 3:30pm.
The first of the two finals in Thurles this afternoon is Irish Daily Star National Camogie League decider between Galway and Kilkenny, who defeated Tipperary in the semi-finals.
Throw-in for that one is at 1.30pm.
