Last night's 3-2 defeat at home to Olympiacos was their second in as many games, with home and away games with Bayern Munich to come.
Bayern top Group F after a Robert Lewandowski hat-trick helped them to a 5-nil victory over Dinamo Zagreb.
Chelsea also suffered a major set-back, going down 2-1 away to Porto.
Dynamo Kiev are the side who top Group G this morning following their 2-nil win at Maccabi Tel Aviv.
Tonight, Manchester United are without Michael Carrick for the visit of Wolfsburg.
Elsewhere in Group B, P-S-V Eindhoven are away to C-S-K-A Moscow.
Manchester City will look for their first win in Group D when they make the trip to Borussia Moenchengladbach
Elsewhere, Juventus take on Sevilla
In Group A, Real Madrid and Paris Saint Germain are both on the road tonight.
Real are in Sweden to face Malmo; while P-S-G are at Shaktar Donetsk while in Group C, Atletico Madrid take on Benfica.
All of tonight's games have 7.45 starts, bar the meeting of Astana and Galatasaray which kicks off at 5.
