Wyatt Crockett, Brodie Retallick, Richie McCaw and Julian Savea replace Tony Woodcock, Luke Romano, Sam Cane and Waisake Naholo.
Inexperienced centre Tyler Morgan has been named in the Wales fifteen in one of three personnel changes to their side to face South Africa .
He comes in for injured Liam Williams – with George North switching back to the wing for the match at Twickenham.
Prop Gethin Jenkins and flanker Dan Lydiate replace Paul James and Justin Tipuric – who both drop down to the bench.
