Donncha O' Callaghan will captain a side that sees South African centre Pat Howard making his first start, while the one change to the front row is BJ Botha lining out at tighthead prop, alongside Duncan Casey and John Ryan.
O' Callaghan partners Billy Holland in the second row.
Paddy Butler moves to openside flanker, as Robin Copeland comes in at blindside flanker, while CJ Stander returns at number 8.
Elsewhere Duncan Williams partners Ian Keatley in the half-backs, while the back three are Gerhard van den Heever and Ronan O' mahony on the wings and JJ Hanrahan at full-back.
Tipp's Tommy O' Donnell joins fellow internationals Felix Jones and Dave Kilcoyne on the bench.
Meanwhile Ulster have made four changes for the Thomond Park encounter, with Rory Best returning to captain the side.
Ian Humphreys replacing injured out half, Paddy Jackson.
Nick Williams comes in at number 8, with Roger Wilson moving to blindside flanker and Clive Ross dropping to the bench.
Alan O'Connor partners Franco van der Merwe in the second row at the expense of Lewis Stevenson.
Munster XV (v Ulster, Friday, 7:35, Thomond Park): JJ Hanrahan; Gerhard van den Heever, Pat Howard, Denis Hurley, Ronan O'Mahony; Ian Keatley, Duncan Williams; John Ryan, Duncan Casey, BJ Botha, Donncha O'Callaghan (capt), Billy Holland, Robin Copeland, Paddy Butler, CJ Stander
Replacements: Kevin O'Byrne, Dave Kilcoyne, Stephen Archer, Tommy O'Donnell, Sean Dougall, Neil Cronin, Andrew Smith, Felix Jones.
