Cahir's Tommy O'Donnell will line out in the back-row alongside Dave O'Callaghan and Jack O'Donoghue.
His fellow Tipp native Dave Foley is also in the XV – the Clonmel man will partner captain Billy Holland in the second row.
Nenagh's Donnacha Ryan is on the replacements bench but could see some game time in Wales.
This is new Munster Director of Rugby Rassie Erasmus's first competitive game at the helm of the province.
