Tottenham welcome Gent to Wembley tonight needing to overturn a 1-0 deficit.
Striker Harry Kane says changes to the side by the manager doesn't mean they've given up on the competition.
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Meanwhile, Arsenal's Santi Carzola has been ruled out for the remainder of the season.
The creative midfielder was due to return to action next month but an ongoing ankle injury means that he won't now do so.