Deadline-day signing Alex Oxlade-Chamberlain is in line to make his Liverpool debut in their Premier League lunchtime kick-off away to Manchester City.
Liverpool make the trip without playmaker Philippe Coutinho, who is not match fit – depite featuring for Brazil in their recent World Cup qualifiers.
City come into the game without injured captain Vincent Kompany and the suspended Raheem Sterling.
Reds boss Jurgen Klopp says having such a tough game straight after the international break is not ideal.
City manager Pep Guardiola is wary of the threat Liverpool pose
Kick-off is at half-twelve.
In the 3pm games,
Chelsea midfielder Danny Drinkwater is set to make his debut at his former club Leicester.
Leicester have striker Kelechi Iheanacho back from a foot injury.
Southampton are expected to welcome Virgil van Dijk back to their squad for their game against Watford.
Brighton meet West Brom in the top-flight of English football for first time since their goalless draw in 1983.
Wayne Rooney will feature for Everton in their game against Spurs at Goodison Park following his arrest for drink driving.
Arsenal look to bounce back from their 4-nil loss to Liverpool when they host Bournemouth.