Tyler Bleyendaal and Connor Murray are in the half-backs while Nenagh native Donnacha Ryan and CJ Stander come into the second row and back row respectively.
Cahir man Tommy O'Donnell also features in the side selected by Munster Director of Rugby Rassie Erasmus for the clash with the English club in Limerick.
Reds scrum-half Conor Murray knows it's going to be hard match.
