Southampton versus Arsenal is the pick of the games, with the south coast side looking to make it two big Cup wins in one week.
That's the half-five kick-off.
At 3 o'clock, Crystal Palace take on Manchester City with both sides hoping to put their recent league struggles behind them.
Also at 3 – in terms of top-tier sides – Chelsea host Brentford, Spurs take on Wycombe Wanderers, Middlesbrough welcome Accrington Stanley to the Riverside and Burnley face Bristol City.
Championship table-toppers Brighton will hope to avoid an upset when they visit non-league Lincoln City, with Newcastle travelling to Oxford United.
Elsewhere, Blackburn host Blackpool and Huddersfield Town go Rochdale
The early game sees Liverpool go toe-to-toe with Wolves.
It's Liverpool's 8th game of 2017 and they've only got one win so far this year and Reds boss Jurgen Klopp knows that confidence is now an issue.
