Keith Earls is in line to make a first appearance of the season having been named on the bench AND Prop Sean Cronin has recovered from a shoulder injury and is also among the replacements.
Anthony Foley has named a much-changed side to that which lost to Connacht on New Year's day.
Tipp's Dave Foley comes into the second row, alongside Billy Holand.
Despite announcing his impending departure from the province, JJ Hanrahan has been named in the centre.
Felix Jones is restored at full-back, with Simon Zebo manning the left wing and Ronan O'Mahoney the right.
In the pack, there's an all-new front row with Eusebio Guinazu, Kevin O'Byrne and Stephen Archer all coming into the side.
Later tonight, Connacht are in action in the Pro12 as they welcome Edinburgh to the Sportsground at 7:35.
