Jack Carty is back from injury and takes over at 10.
Quinn Roux, Nepia Fox Matmua and Jake Heenan are all included in the pack.
A win will guarantee Connacht a spot in the last eight.
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Meanwhile, Tommy Bowe, Darren Cave, Jonny Simpson and Andy Warwick all come into the Ulster side to face Bordeaux Begles at Kingspan Stadium tomorrow.
Tonight Leinster play Castres in France knowing a win will give them a home quarter-final.
