Nathan Redmond scored the only goal of last night's first leg at St. Mary's.
Captain for the night Virgil Van Dijk feels they can contain the Reds again in a fortnight's time.
Reading can move to within three points of the Championship's top two tonight.
But, they face a QPR side who have returned to form under Ian Holloway.
Kick off at the Madejski is at 8.