The pairings will be announced live here on Tipp FM by County secretary Tim Floyd on the Extra Time Sports show with Ronan Quirke from 7pm.
Three of the four semi finalists are known in the Tipperary football championship.
Arravale Rovers, Moyle Rovers and Clonmel Commercials all won their quarter final games over the weekend.
Eire Óg Annacarthy and Aherlow Gaels will meet in the final quarter final game on Wednesday night.
Speaking to Tipp FM Sport, Clonmel Commercials Chairman Derek Williams said having a wealth of county players has benefitted the club.
