Jurgen Klopp's side have travelled to London to face West Ham, a side who comfortably beat them 3-0 at Anfield in August.
At 3, leaders Arsenal welcome struggling Newcastle to the Emirates.
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Second placed Leicester go up against Bournemouth at the King Power.
Manchester United are eight games without a win, and almost two years without a victory over today's opponents Swansea.
The bottom two meet at the Stadium of Light, with Sunderland up against Aston Villa.
Elsewhere, West Brom have Stoke, and Norwich play Southampton.
While third placed Manchester City could end the day top of the table if they beat Watford in the late kick off, and the top two lost
