Both players have come through the return-to-play protocols after a bruising affair last week.
Keith Earls starts on the wing in place of Simon Zebo, while Garry Ringrose comes into the centre replacing the injured Robbie Henshaw.
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As he did off the bench last week, Paddy Jackson comes in for Jonathan Sexton.
In the pack, Iain Henderson comes in for Tipperary's Donnacha Ryan in the second row,
Head coach Joe Schmidt feels Kearney and Stander will be fine come Saturday.
