Payne will start at full-back having recovered from the foot injury he sustained at the World Cup.
Andrew Trimble returns on the wing.
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Ulster are the only Irish side who can still make the quarter finals
Meanwhile, Gary Ringrose gets his first European start for Leinster in tomorrows clash with Bath in the RDS.
Luke McGrath, Peter Dooley, James Tracy, Tadhg Furlong and Ross Molony all also make their first European starts.
