Clonmel's Dave Foley is in the engine room while Cahir native Tommy O'Donnell will line out in the back three.
Cistercian College Roscrea's Fineen Wycherley is included in a Pro12 squad for the first time.
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Darren Sweetnam continues on the wing after making his comeback from injury last week in the Reds' narrow win away to the Ospreys .
The Corkman has been outlining the importance of this match.
Meanwhile, Connacht assistant coach Conor Mc Phillips is leaving the province at the end of the season.
The Backs coach will join with Pat Lam at Bristol.
Earlier in the season Lam confirmed his departure and this week it was confirmed he'll be replaced by Kieran Keane.
