France will play host to Italy in the opening game of this year's tournament, with kick-off at the Stade de France at 2:25pm.
That game will be followed by the Calcutta Cup contest between Scotland and England at Murrayfield.
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The action in Edinburgh begins at 4:50pm.
Meanwhile, the Ireland Womens team will begin the defence of their Six Nations title this afternoon.
Tom Tierney's side will play host to their Welsh counter-parts at their new home in Donnybrook after several years playing their home matches in Ashbourne.
Kick-off in Ashbourne is at 1 o'clock, with the meeting of France and Italy taking place tonight at 8pm.