They host bottom team Swansea.
Paul Clement's still looking for his first win in charge of the visitors – after losses to Hull and Arsenal.
Anfield boss Jurgen Klopp says he can see a big difference since Clement took over.
The pick of the ties is the evening game where an in-form Tottenham side travel to the Etihad to face struggling Manchester City.
City were hammered 4-0 by Everton last time out, while Spurs won their seventh straight game with a comfortable win over West Brom.
Kick off is at 5.30pm.
Five more games get underway at 3pm.
Manchester United bring their 17-game unbeaten run to the Bet365 Stadium as they face Stoke City.
Everton travel to London to meet Crystal Palace.
Bournemouth take on Watford.
Middlesbrough play host to West Ham United.
And bottom side Sunderland make the trip to West Brom.
