Scrum-half Kieran Marmion and full-back Jared Payne are in for injured duo Conor Murray and Rob Kearney on the Ireland team with Iain Henderson preferred to Devin Toner in the second-row where he'll link up with Tipperary's Donnacha Ryan.
Despite the title slipping away from Ireland last weekend, head-coach Joe Schmidt says his side are motivated to win this evening.
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Kick-off at the Aviva Stadium is at 5 o'clock – we'll have updates on Tipp FM.
Scotland take on winless Italy at Murrayfield at 12.30pm.
While Ireland will be hoping that France defeat Wales in Paris at 2.45pm.
Victory for the Welsh would see them move up to the top four of world rankings ahead of the World Cup draw.
