Last term's top two meet at the Etihad, where champions Chelsea pay a visit to Manchester City.
Manuel Pellegrini says it's too early to speak of title challenges, but he is focused on winning all three points.
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After their opening day loss to West Ham, Arsenal face another tricky London derby this lunchtime.
Arsene Wenger's side cross the Thames to face Crystal Palace at Selhurst Park.
The Gunners boss believes his side have the character to bounce back from last week's loss.
Kick off at Selhurst Park is at 1.30.
