Head Coach Rob Penney has made one change from the side that beat Gloucester for Sunday's Pool 6 match at Thomond Park.
Stephen Archer will line out at tight-head prop alongside Damien Varley and Dave Kilcoyne, with BJ Botha moving to the replacements.
Paddy Butler is also on the bench and is included in a Heineken Cup squad for the first time.
Munster XV v Edinburgh: Felix Jones; Keith Earls, Casey Laulala, James Downey, Johne Murphy; Ian Keatley, Conor Murray; Dave Kilcoyne, Damien Varley, Stephen Archer; Dave Foley, Paul O'Connell; Peter O'Mahony Capt., Tommy O'Donnell, James Coughlan.
Replacements: Duncan Casey, James Cronin, BJ Botha, Donncha O'Callaghan, Paddy Butler, Duncan Williams, JJ Hanrahan, Simon Zebo.