Munster loosehead Dave Kilcoyne will make his first start of the season tomorrow at home to Ospreys
Donncha O'Callaghan comes into the second row for Billy Holland and Munster's most capped player will be partnered by Paul O'Connell who makes his second consecutive league start.
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There's no room in the starting 15 for Tipperary's Dave Foley or Tommy O'Donnell, although Foley is named in the replacements.
Sean Dougall and CJ Stander return to the starting line up at 7 and 8 respectively.
In the half backs Conor Murray will captain the side from scrum half, while Ian Keatley is back to take command of the 10 channel.