Tries in either half from Shane Jennings and Zane Kirchner saw Matt O'Connor's side run out 21-11 winners against Connacht at the RDS.
Winger Michael Allen and loosehead prop, Andrew Warwick come into the Ulster side that takes on the Ospreys at the Liberty Stadium later.
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Leaders Munster is also away from home today – a much-changed side have travelled to Glasgow to take on the Warriors with kick off at 2.40.
Despite epic back-to-back battles with Clermont in the Champions Cup, winger Andrew Conway says there's no chance of the squad treating today's game a lesser challenge.