Goals from Sergio Aguero, David Silva and Yaya Toure have left City in control ahead of the return match in Manchester on the 15th of March.
Meanwhile, 10-man PSV Eindhoven held-out for a scoreless draw against Atletico Madrid in last night's other last-16 match in the Netherlands.
Liverpool, Man United and Tottenham are all in action tonight in the last-32 of the Europa League.
Liverpool will be first into action as they play host to Augsburg at Anfield after a scoreless draw in their first-leg tie in Germany.
Kick-off in that one is at 6pm.
United and Spurs will both be involved in five-past eight starts tonight.
United will play host to FC Midtjylland after the Danish side claimed a 2-1 win in the first-leg last week.
And it's tied 1-all between Tottenham and Fiorentina ahead of their second-leg tie at White Heart Lane.
